Exercises in molecular gymnastics--bending, stretching and twisting porphyrins.
نویسنده
چکیده
The functional versatility of tetrapyrroles as natural cofactors is related to their conformational flexibility where manipulation of the macrocycle conformation allows a fine-tuning of their physicochemical properties. This feature article gives a personal account of the synthesis and solid state structural characterization of highly substituted, non-planar porphyrins. Their conformational analysis identifies sterically strained tetrapyrroles as a versatile class of biomimetic compounds with tailor-made properties.
منابع مشابه
Twisting and stretching single DNA molecules.
The elastic properties of DNA are essential for its biological function. They control its bending and twisting as well as the induction of structural modifications in the molecule. These can affect its interaction with the cell machinery. The response of a single DNA molecule to a mechanical stress can be precisely determined in single-molecule experiments which give access to an accurate measu...
متن کاملStretching the Spines of Gymnasts: A Review
Gymnastics is noted for involving highly specialized strength, power, agility and flexibility. Flexibility is perhaps the single greatest discriminator of gymnastics from other sports. The extreme ranges of motion achieved by gymnasts require long periods of training, often occupying more than a decade. Gymnasts also start training at an early age (particularly female gymnasts), and the effect ...
متن کاملLocal elasticity of strained DNA studied by all-atom simulations.
Genomic DNA is constantly subjected to various mechanical stresses arising from its biological functions and cell packaging. If the local mechanical properties of DNA change under torsional and tensional stress, the activity of DNA-modifying proteins and transcription factors can be affected and regulated allosterically. To check this possibility, appropriate steady forces and torques were appl...
متن کاملGeometric aspects of discrete elastic rods
Elastic rods are curve-like elastic bodies that have one dimension (length) much larger than the others (cross-section). Their elastic energy breaks down into three contributions: stretching, bending, and twisting. Stretching and bending are captured by the deformation of a space curve called the centerline, while twisting is captured by the rotation of a material frame associated to each point...
متن کاملA tool to monitor and support physical exercise interventions for MCI and AD patients
This paper presents a tool to support and monitor the execution of common physical exercise interventions targeting people with Mild Cognitive Impairment (MCI), Alzheimer’s disease (AD) and elderly in general. Our tool aims (a) to stimulate and guide patients within physical exercise programs, (b) to monitor patient capacity to perform exercises suggested by clinicians, providing objective feed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 3 شماره
صفحات -
تاریخ انتشار 2006